![]() ![]() Therefore, to overcome these shortcomings, it is essential to further explore the structural characteristics and mechanism of action of AMPs to improve their stability, activity, targeting, and reduction of cytotoxicity. ![]() While a few AMPs have entered the clinical stage of cancer treatment, the inevitable defects in the natural AMPs are the obstacles to development of AMPs with therapeutic efficacy. At present, the clinical application of AMPs is mainly on the treatment of pathogenic bacteria infection, wound healing and inflammation. AMPs have antibacterial and anticancer properties, and thus is a new treatment option for cancer patients. Furthermore, the long-term chemotherapy in cancer patients not only leads to resistance to conventional cancer treatments, but also results in the susceptibility to pathogenic infection. Thus, AMPs provide a new alternative to antibiotics. In contrast, AMPs show the advantages by acting on multiple targets on the plasma membrane and intracellular targets of pathogenic bacteria, and have potent activity on drug-resistant bacteria. However, the emergence of drug resistance due to the single target of antibiotics, long-term and extensive utilization, is becoming a major challenge for clinical infection management. The treatment of pathogenic bacteria has been long-time mainly relied on antibiotics. Besides antibacterial activities, AMPs have been found to possess a variety of biological functions, such as immune regulation, angiogenesis, wound healing and antitumor activity. To date, the AMP database has reported 3791 AMPs from six kingdoms, including 431 from bacteria, 4 from archaea, 7 from protozoal, 6 from fungal, 824 from plants and 2519 from animals. Antimicrobial peptides (AMPs) are the small molecular peptides that play a crucial role in the innate immunity of the host against a broad range of microorganisms, including bacteria, fungi, parasites and viruses. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |